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KMID : 0370020030170000053
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Chung-Ang Journal of Pharmacal Sciences
2003 Volume.17 No. 0 p.53 ~ p.59
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Correlation of Inflammatory Mediators and Melanin Production
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Abstract
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The epidermal environment contains multiple inflammatory mediators, cytokines and growth factors that may alter constitutive melanocyte function. Constitutive melanocyte function can also be markedly altered by release of inflammatory mediators, such as ATP, histamine, arachidonic acid and its metabolites To investigate correlation of inflammatory mediators and melanin production, we examined effects of inflammatory mediators on tyrosinase activity and melanin production in B16 melanoma cells. Both ATP and histamine significantly inhibited tyrosinase activity and melanin production in B16 melanoma cells. Melittin significantly stimulated tyrosinase activity and melanin production in the absence or presence of MSH in B16 melanoma cells. These results suggest that arachidonic acid and its metabolites may be associated with the hyperpigmentation in inflammatory lesions.
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